Early rheumatoid arthritis is associated with diminished numbers of TH1 cells in stimulated peripheral blood

被引：9

作者：

Mangge, H

Felsner, P

Herrmann, J

El-Shabrawi, Y

Liebmann, P

Schauenstein, K

机构：

[1] Graz Univ, Sch Med, Dept Lab Med, Graz, Austria

[2] Graz Univ, Sch Med, Dept Pediat Immunol Rheumatol, Graz, Austria

[3] Graz Univ, Sch Med, Dept Internal Med, Graz, Austria

[4] Graz Univ, Sch Med, Dept Ophthalmol, Graz, Austria

[5] Graz Univ, Sch Med, Dept Gen & Expt Pathol, Graz, Austria

来源：

IMMUNOBIOLOGY | 1999年 / 200卷 / 02期

关键词：

D O I：

10.1016/S0171-2985(99)80077-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Rheumatoid arthritis (RA) has been associated with an altered TH1/TH2 balance. Here we present first results with a technique to quantitate stimulated TH1 and TH2 subsets in whole blood by means of cytofluorimetric detection of intracytoplasmic TH1 and TH2 cytokiner. A group of 10 patients suffering from initial stages of RA exhibited a significantly reduced percentage of TH1 cells (11.0 + 2.0%) in the peripheral blood as compared to 13 healthy, age matched controls (28.8 +/- 2.0%). The TH2 response, as determined by intracellular expression of IL-4, remained unchanged. The data may indicate a defect in the TH0-TH1 differentiation or/and a selective trapping of TH1 cells into the affected joints.

引用

页码：290 / 294

页数：5

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