The phase 0 microdosing concept

被引:67
作者
Garner, RC [1 ]
Lappin, G [1 ]
机构
[1] Xceleron Ltd, York Bioctr, York YO10 5NY, N Yorkshire, England
关键词
D O I
10.1111/j.1365-2125.2006.02575.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:367 / 370
页数:4
相关论文
共 10 条
[1]   In vivo pharmacokinetics and pharmacodynamics in drug development using positron-emission tomography [J].
Aboagye, EO ;
Price, PM ;
Jones, T .
DRUG DISCOVERY TODAY, 2001, 6 (06) :293-302
[2]  
[Anonymous], 2004, INN STAGN CHALL OPP
[3]   Positron emission tomography microdosing:: a new concept with application in tracer and early clinical drug development [J].
Bergström, M ;
Grahnén, A ;
Långström, B .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2003, 59 (5-6) :357-366
[4]  
Committee for Medicinal Products for Human Use EMA, 2004, CPMPSWP259902REV1 EM
[5]   The price of innovation: new estimates of drug development costs [J].
DiMasi, JA ;
Hansen, RW ;
Grabowski, HG .
JOURNAL OF HEALTH ECONOMICS, 2003, 22 (02) :151-185
[6]   Modern biomedical research: an internally self-consistent universe with little contact with medical reality? [J].
Horrobin, DF .
NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (02) :151-154
[7]   Current perspectives of 14C-isotope measurement in biomedical accelerator mass spectrometry [J].
Lappin, G ;
Garner, RC .
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2004, 378 (02) :356-364
[8]   Big physics, small doses: the use of AMS and PET in human microdosing of development drugs [J].
Lappin, G ;
Garner, RC .
NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (03) :233-240
[9]  
*US DEP HHS FOOD D, 2006, GUID IND EXPL IND ST
[10]  
2003, PAREXELS PHARM R D S