Unique hybrids between the fungal pathogens Cryptococcus neoformans and Cryptococcus gattii

被引：110

作者：

Bovers, Marjan

Hagen, Ferry

Kuramae, Eiko E.

Diaz, Mara R.

Spanjaard, Lodewijk

Dromer, Francoise

Hoogveld, Hans L.

Boekhout, Teun

机构：

[1] Cent Bur Schimmelcultures, KNAW, NL-3584 CT Utrecht, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Dept Med Microbiol, Netherlands Reference Lab Bacterial Meningitis, NL-1105 AZ Amsterdam, Netherlands

[3] Inst Pasteur, CNRS, FRE2849, Ctr Natl Reference Mycol & Antifong, Paris, France

[4] Netherlands Inst Ecol, NIOO, KNAW, Nieuwersluis, Netherlands

来源：

FEMS YEAST RESEARCH | 2006年 / 6卷 / 04期

关键词：

Cryptococcus neoformans; Cryptococcus gattii; BD hybrid; recurrent meningitis;

D O I：

10.1111/j.1567-1364.2006.00082.x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cryptococcus neoformans and Cryptococcus gattii are yeasts that cause meningoencephalitis, but that differ in host range and geographical distribution. Cryptococcus neoformans occurs world-wide and mostly infects immunocompromised patients, whereas C. gattii occurs mainly in (sub)tropical regions and infects healthy individuals. Anomalous C. neoformans strains were isolated from patients. These strains were found to be monokaryotic, and diploid or aneuploid. Amplified Fragment Length Polymorphism (AFLP) and sequence analyses indicated that AFLP genotypes 2 (C. neoformans) and 4 (C. gattii) were present. The strains were serologically BD. Mating- and serotype-specific PCR reactions showed that the strains were MATa-serotype D/MAT alpha-serotype B. This study is the first to describe naturally occurring hybrids between C. neoformans and C. gattii.

引用

页码：599 / 607

页数：9

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