L-NA-sensitive rCBF augmentation during vibrissal stimulation in type III nitric oxide synthase mutant mice

被引：75

作者：

Ayata, C

Ma, JY

Meng, W

Huang, P

Moskowitz, MA

机构：

[1] HARVARD UNIV,SCH MED,MASSACHUSETTS GEN HOSP,DEPT NEUROSURG & NEUROL,CHARLESTOWN,MA 02129

[2] HARVARD UNIV,SCH MED,MASSACHUSETTS GEN HOSP,CARDIOVASC RES CTR,CHARLESTOWN,MA 02129

[3] HARVARD UNIV,SCH MED,MASSACHUSETTS GEN HOSP,DEPT MED,CHARLESTOWN,MA 02129

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 1996年 / 16卷 / 04期

关键词：

nitric oxide; cerebral blood flow; mice; knockout; coupling;

D O I：

10.1097/00004647-199607000-00002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Regional cerebral blood flow (rCBF) was studied in type III nitric oxide (NO) synthase (endothelial, eNOS) mutant and wild type mice during mechanical whisker stimulation before and after nitro-L-arginine (L-NA) superfusion using the closed cranial window technique. rCBF increased equally in cortical barrel fields in both strains during stimulation, as measured by laser Doppler-flowmetry, and was inhibited by L-NA superfusion (1 mM) in both groups. Hence, coupling of blood flow and metabolism appears neuronal NOS- (nNOS) but not eNOS-dependent in cortical barrel fields of the mouse.

引用

页码：539 / 541

页数：3

共 10 条

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