The mitogen-activated protein kinase homolog HOG1 gene controls glycerol accumulation in the pathogenic fungus Candida albicans

被引：147

作者：

SanJose, C ^{[1
]}

Monge, RA ^{[1
]}

PerezDiaz, R ^{[1
]}

Pla, J ^{[1
]}

Nombela, C ^{[1
]}

机构：

[1] UNIV COMPLUTENSE MADRID,FAC FARM,DEPT MICROBIOL 2,E-28040 MADRID,SPAIN

来源：

JOURNAL OF BACTERIOLOGY | 1996年 / 178卷 / 19期

关键词：

D O I：

10.1128/jb.178.19.5850-5852.1996

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Candida albicans HOG1 gene (HOG1(Ca)) was cloned by functional complementation of the osmosensitive phenotype associated with Saccharomyces cerevisiae hog1 Delta mutants. HOG1(Ca) codes for a 377-amino-acid protein, 78% identical to S. cerevisiae Hog1p. A C. albicans hog1 null mutant was found to be sensitive to osmotic stress and failed to accumulate glycerol on high-osmolarity media.

引用

页码：5850 / 5852

页数：3

共 21 条

[1] GPD1, WHICH ENCODES GLYCEROL-3-PHOSPHATE DEHYDROGENASE, IS ESSENTIAL FOR GROWTH UNDER OSMOTIC-STRESS IN SACCHAROMYCES-CEREVISIAE, AND ITS EXPRESSION IS REGULATED BY THE HIGH-OSMOLARITY GLYCEROL RESPONSE PATHWAY [J].

ALBERTYN, J ;

HOHMANN, S ;

THEVELEIN, JM ;

PRIOR, BA .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (06) :4135-4144

[2] SEX, STRESS AND INTEGRITY - THE IMPORTANCE OF MAP KINASES IN YEAST [J].

AMMERER, G .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1994, 4 (01) :90-95

[3] ROLES OF GLYCEROL AND GLYCEROL-3-PHOSPHATE DEHYDROGENASE (NAD+) IN ACQUIRED OSMOTOLERANCE OF SACCHAROMYCES-CEREVISIAE [J].

BLOMBERG, A ;

ADLER, L .

JOURNAL OF BACTERIOLOGY, 1989, 171 (02) :1087-1092

[4] PHYSIOLOGY OF OSMOTOLERANCE IN FUNGI [J].

BLOMBERG, A ;

ADLER, L .

ADVANCES IN MICROBIAL PHYSIOLOGY, 1992, 33 :145-212

[5] AN OSMOSENSING SIGNAL TRANSDUCTION PATHWAY IN YEAST [J].

BREWSTER, JL ;

DEVALOIR, T ;

DWYER, ND ;

WINTER, E ;

GUSTIN, MC .

SCIENCE, 1993, 259 (5102) :1760-1763

[6] PARALLEL SIGNAL-PROCESSING AMONG MAMMALIAN MAPKS [J].

CANO, E ;

MAHADEVAN, LC .

TRENDS IN BIOCHEMICAL SCIENCES, 1995, 20 (03) :117-122

[7] MOLECULAR-BASIS OF CELL INTEGRITY AND MORPHOGENESIS IN SACCHAROMYCES-CEREVISIAE [J].

CID, VJ ;

DURAN, A ;

DELREY, F ;

SNYDER, MP ;

NOMBELA, C ;

SANCHEZ, M .

MICROBIOLOGICAL REVIEWS, 1995, 59 (03) :345-386

[8]

Degols G, 1996, MOL CELL BIOL, V16, P2870

[9] CLONING AND CHARACTERIZATION OF GPD2, A 2ND GENE ENCODING SN-GLYCEROL 3-PHOSPHATE DEHYDROGENASE (NAD(+)) IN SACCHAROMYCES-CEREVISIAE, AND ITS COMPARISON WITH GPD1 [J].

ERIKSSON, P ;

ANDRE, L ;

ANSELL, R ;

BLOMBERG, A ;

ADLER, L .

MOLECULAR MICROBIOLOGY, 1995, 17 (01) :95-107

[10] A conserved kinase cascade for MAP kinase activation in yeast [J].

Errede, Beverly ;

Levin, David E. .

CURRENT OPINION IN CELL BIOLOGY, 1993, 5 (02) :254-260

← 1 2 3 →