Tumor necrosis factor α antibody prevents brain damage of rats with acute necrotizing pancreatitis

被引：68

作者：

Yang, Yan-Ling ^{[1
]}

Li, Ji-Peng ^{[1
]}

Li, Kai-Zong ^{[1
]}

Dou, Ke-Feng ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Dept Hepatobiliary Surg, Xijing Hosp, Xian 710032, Shaanxi, Peoples R China

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2004年 / 10卷 / 19期

关键词：

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM: To study the protective effects of tumor necrosis factor alpha (TNF alpha) antibody on pancreatic encephalopathy in rats. METHODS: One hundred and twenty SD rats were randomly divided into normal control group, acute necrotizing pancreatitis group and TNF alpha antibody treated group. Acute hemorrhage necrotizing pancreatitis model in rats was induced by retrograde injection of 50 g/L sodium taurocholate into the pancreatobiliary duct. Serum TNF alpha was detected and animals were killed 12 h after drug administration. Changes in content of brain water, MDA and SOD as well as leucocyte adhesion of brain microvessels were measured. RESULTS: In TNF alpha antibody treated group, serum TNF alpha level was decreased. Content of brain water, MDA and SOD as well as leucocyte adhesion were decreased significantly in comparison with those of acute necrotizing pancreatitis group (P<0.05). CONCLUSION: TNF alpha antibody can alleviate the brain damage of rats with acute hemorrhage necrotizing pancreatitis.

引用

页码：2898 / 2900

页数：3

共 40 条

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