p53 Family members p63 and p73 are SAM domain-containing proteins

被引：126

作者：

Thanos, CD

Bowie, JU ^{[1
]}

机构：

[1] Univ Calif Los Angeles, DOE, Lab Struct Biol & Mol Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

来源：

PROTEIN SCIENCE | 1999年 / 8卷 / 08期

关键词：

Sterile Alpha Motif; tumor suppressor;

D O I：

10.1110/ps.8.8.1708

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Homologs of the tumor suppressor p53, called p63 and p73, have been identified. The p63 and p73 family members possess a domain structure similar to p53, but contain variable C-terminal extensions. We find that some of the C-terminal extensions contain Sterile Alpha Motif (SAM) domains. SAM domains are protein modules that an involved in protein-protein interactions. Consistent with this role, the C-terminal SAM domains of the p63 and p73 may regulate function by recruiting other protein effecters.

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收藏

页码：1708 / 1710

页数：3

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