The Origins and Drivers of Insulin Resistance

被引：553

作者：

Johnson, Andrew M. F. ^{[1
]}

Olefsky, Jerrold M. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

来源：

CELL | 2013年 / 152卷 / 04期

关键词：

DIET-INDUCED OBESITY; HIGH-FAT DIET; NECROSIS-FACTOR-ALPHA; KILLER T-CELLS; ADIPOSE-TISSUE; GUT MICROBIOTA; METABOLIC-SYNDROME; PPAR-GAMMA; MOLECULAR-MECHANISMS; GLUCOSE-TOLERANCE;

D O I：

10.1016/j.cell.2013.01.041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Obesity-induced insulin resistance is the major determinant of metabolic syndrome, which precedes the development of type 2 diabetes mellitus and is thus the driving force behind the emerging diabetes epidemic. The precise causes of insulin resistance are varied, and the relative importance of each is a matter of ongoing research. Here, we offer a Perspective on the heterogeneous etiology of insulin resistance, focusing in particular on the role of inflammation, lipid metabolism, and the gastrointestinal microbiota.

引用

页码：673 / 684

页数：12

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