Oncogenic aberrations of cullin-dependent ubiquitin ligases

被引：74

作者：

Guardavaccaro, D

Pagano, M

机构：

[1] NYU, Sch Med, Dept Pathol, New York, NY 10016 USA

[2] NYU, Sch Med, Inst Canc, New York, NY 10016 USA

来源：

ONCOGENE | 2004年 / 23卷 / 11期

关键词：

ubiquitin; cancer; cullin; cell cycle;

D O I：

10.1038/sj.onc.1207413

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Accumulating evidence points to a key role of the ubiquitin - proteasome pathway in oncogenesis. Aberrant proteolysis of substrates involved in cellular processes such as the cell division cycle, gene transcription, the DNA damage response and apoptosis has been reported to contribute significantly to neoplastic transformation. Cullin-dependent ubiquitin ligases (CDLs) form a class of structurally related multisubunit enzymes central to the ubiquitin-mediated proteolysis of many important biological substrates. In this review, we describe the role of CDLs in the ubiquitinylation of cancer-related substrates and discuss how altered ubiquitinylation by CDLs may contribute to tumor development.

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收藏

页码：2037 / 2049

页数：13

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