Clinical review 145 - Pleiotropic effects of statins: Lipid reduction and beyond

被引：252

作者：

McFarlane, SI

Muniyappa, R

Francisco, R

Sowers, JR

机构：

[1] SUNY Hlth Sci Ctr, Dept Med, Div Endocrinol Diabet & Hypertens, Brooklyn, NY 11203 USA

[2] SUNY Hlth Sci Ctr, Dept Cell Biol, Brooklyn, NY 11203 USA

[3] Vet Adm Med Ctr, Brooklyn, NY 11209 USA

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2002年 / 87卷 / 04期

关键词：

D O I：

10.1210/jc.87.4.1451

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is accumulating evidence that statins have beneficial effects that are independent of their classical actions on lipoproteins. These effects include reductions in inflammation in the vasculature, kidney, and bone. Potential beneficial effects of these agents include enhancement of nitric oxide production in vasculature and the kidney. These agents appear to reduce bone fractures and may improve insulin sensitivity and reduce the likelihood of persons progressing from impaired glucose tolerance to type II diabetes. Potential beneficial pleiotropic effects of statins are covered in this review.

引用

收藏

页码：1451 / 1458

页数：8

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