Towards a molecular architecture of centriole assembly

被引:229
作者
Goenczy, Pierre [1 ]
机构
[1] Swiss Fed Inst Technol EPFL, Swiss Inst Expt Canc Res ISREC, Sch Life Sci, Lausanne, Switzerland
基金
瑞士国家科学基金会; 欧洲研究理事会;
关键词
C. ELEGANS EMBRYOS; CENTROSOME DUPLICATION; BASAL BODY; HUMAN-CELLS; CAENORHABDITIS-ELEGANS; 9-FOLD SYMMETRY; PROCENTRIOLE FORMATION; REGULATES CENTRIOLE; DAUGHTER CENTRIOLE; EPITHELIAL-CELLS;
D O I
10.1038/nrm3373
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The centriole is an evolutionarily conserved macromolecular structure that is crucial for the formation of flagella, cilia and centrosomes. The ultrastructure of the centriole was first characterized decades ago with the advent of electron microscopy, revealing a striking ninefold radial arrangement of microtubules. However, it is only recently that the molecular mechanisms governing centriole assembly have begun to emerge, including the elucidation of the crucial role of spindle assembly abnormal 6 (SAS-6) proteins in imparting the ninefold symmetry. These advances have brought the field to an exciting era in which architecture meets function.
引用
收藏
页码:425 / 435
页数:11
相关论文
共 109 条
[2]   SPICE - a previously uncharacterized protein required for centriole duplication and mitotic chromosome congression [J].
Archinti, Marco ;
Lacasa, Cristina ;
Teixido-Travesa, Neus ;
Luders, Jens .
JOURNAL OF CELL SCIENCE, 2010, 123 (18) :3039-3046
[3]   Cell-cycle-regulated expression of STIL controls centriole number in human cells [J].
Arquint, Christian ;
Sonnen, Katharina F. ;
Stierhof, York-Dieter ;
Nigg, Erich A. .
JOURNAL OF CELL SCIENCE, 2012, 125 (05) :1342-1352
[4]  
Azimzadeh J., 2004, CENTROSOME EVOLUTION, P93
[5]   Structure and duplication of the centrosome [J].
Azimzadeh, Juliette ;
Bornens, Michel .
JOURNAL OF CELL SCIENCE, 2007, 120 (13) :2139-2142
[6]   Centrosome Loss in the Evolution of Planarians [J].
Azimzadeh, Juliette ;
Wong, Mei Lie ;
Downhour, Diane Miller ;
Alvarado, Alejandro Sanchez ;
Marshall, Wallace F. .
SCIENCE, 2012, 335 (6067) :461-463
[7]   Building the Centriole [J].
Azimzadeh, Juliette ;
Marshall, Wallace F. .
CURRENT BIOLOGY, 2010, 20 (18) :R816-R825
[8]   hPOC5 is a centrin-binding protein required for assembly of full-length centrioles [J].
Azimzadeh, Juliette ;
Hergert, Polla ;
Delouvee, Annie ;
Euteneuer, Ursula ;
Formstecher, Etienne ;
Khodjakov, Alexey ;
Bornens, Michel .
JOURNAL OF CELL BIOLOGY, 2009, 185 (01) :101-114
[9]   Flies without centrioles [J].
Basto, Renata ;
Lau, Joyce ;
Vinogradova, Tatiana ;
Gardiol, Alejandra ;
Woods, C. Geoffrey ;
Khodjakov, Alexey ;
Raff, Jordan W. .
CELL, 2006, 125 (07) :1375-1386
[10]   SAK/PLK4 is required for centriole duplication and flagella development [J].
Bettencourt-Dias, M ;
Rodrigues-Martins, A ;
Carpenter, L ;
Riparbelli, M ;
Lehmann, L ;
Gatt, MK ;
Carmo, N ;
Balloux, F ;
Callaini, G ;
Glover, DM .
CURRENT BIOLOGY, 2005, 15 (24) :2199-2207