Blockade of glucocorticoid excess at the tissue level:: Inhibitors of 11β-hydroxysteroid dehydrogenase type 1 as a therapy for type 2 diabetes

被引：54

作者：

Fotsch, Christopher ^{[2
]}

Wang, Minghan ^{[1
]}

机构：

[1] Amgen Inc, Dept Metab Disorders, Thousand Oaks, CA 91320 USA

[2] Amgen Inc, Dept Med Chem, Thousand Oaks, CA 91320 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2008年 / 51卷 / 16期

关键词：

D O I：

10.1021/jm800369f

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

引用

页码：4851 / 4857

页数：7

共 49 条

[1]

Increased expression of 11β-hydroxysteroid dehydrogenase type 1 in type 2 diabetic myotubes [J].

Abdallah, BM ;

Beck-Nielsen, H ;

Gaster, M .

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2005, 35 (10) :627-634

[2]

Effects of the 11β-hydroxysteroid dehydrogrenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes [J].

Andrews, RC ;

Rooyackers, O ;

Walker, BR .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (01) :285-291

[3]

Adrenal corticosteroid biosynthesis, metabolism, and action [J].

Arlt, W ;

Stewart, PM .

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 2005, 34 (02) :293-+

[4]

Diagnosis and complications of Cushing's syndrome: A consensus statement [J].

Arnaldi, G ;

Angeli, A ;

Atkinson, AB ;

Bertagna, X ;

Cavagnini, F ;

Chrousos, GP ;

Fava, GA ;

Findling, JW ;

Gaillard, RC ;

Grossman, AB ;

Kola, B ;

Lacroix, A ;

Mancini, T ;

Mantero, F ;

Newell-Price, J ;

Nieman, LK ;

Sonino, N ;

Vance, ML ;

Giustina, A ;

Boscaro, M .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (12) :5593-5602

[5]

Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs.: Discovery of potent and selective inhibitors of the 11β-hydroxysteroid dehydrogenase type 1 [J].

Barf, T ;

Vallgårda, J ;

Emond, R ;

Häggström, C ;

Kurz, G ;

Nygren, A ;

Larwood, V ;

Mosialou, E ;

Axelsson, K ;

Olsson, R ;

Engblom, L ;

Edling, N ;

Rönquist-Nii, Y ;

Öhman, B ;

Alberts, P ;

Abrahmsén, L .

JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (18) :3813-3815

[6]

Demonstration of proof of mechanism and pharmacokinetics and pharmacodynamic relationship with 4′-cyano-biphenyl-4-sulfonic acid (6-amino-pyridin-2-yl)-amide (PF-915275), an inhibitor of 11β-hydroxysteroid dehydrogenase type 1, in cynomolgus monkeys [J].

Bhat, B. Ganesh ;

Hosea, Natilie ;

Fanjul, Andrea ;

Herrera, Jocelyn ;

Chapman, Justin ;

Thalacker, Fred ;

Stewart, Paul M. ;

Rejto, Paul A. .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2008, 324 (01) :299-305

[7]

HYPERCORTISOLISM IN DIABETES-MELLITUS [J].

CAMERON, OG ;

THOMAS, B ;

TIONGCO, D ;

HARIHARAN, M ;

GREDEN, JF .

DIABETES CARE, 1987, 10 (05) :662-664

[8]

Successful long-term treatment of refractory Cushing's disease with high-dose mifepristone (RU 486) [J].

Chu, JW ;

Matthias, DF ;

Belanoff, J ;

Schatzberg, A ;

Hoffman, AR ;

Feldman, D .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (08) :3568-3573

[9]

Perhydroquinolylbenzamides as novel inhibitors of 11β-hydroxysteroid dehydrogenase type 1 [J].

Coppola, GM ;

Kukkola, PJ ;

Stanton, JL ;

Neubert, AD ;

Marcopulos, N ;

Bilci, NA ;

Wang, H ;

Tomaselli, HC ;

Tan, J ;

Aicher, TD ;

Knorr, DC ;

Jeng, AY ;

Dardik, B ;

Chatelain, RE .

JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (21) :6696-6712

[10]

Modulation of 11β-hydroxysteroid dehydrogenase (11βHSD) activity biomarkers and pharmacokinetics of PF-00915275, a selective 11βHSD1 inhibitor [J].

Courtney, Rachel ;

Stewart, Paul M. ;

Toh, Melvin ;

Ndongo, Marie-Noella ;

Calle, Roberto A. ;

Hirshberg, Boaz .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2008, 93 (02) :550-556

← 1 2 3 4 5 →