Vsx1, a rapidly evolving paired-like homeobox gene expressed in cone bipolar cells

被引：88

作者：

Chow, RL

Snow, B

Novak, J

Looser, J

Freund, C

Vidgen, D

Ploder, L

McInnes, RR ^{[1
]}

机构：

[1] Univ Toronto, Dept Mol & Med Genet, Toronto, ON M5S 1A1, Canada

[2] Hosp Sick Children, Res Inst, Program Dev Biol, Toronto, ON M5G 1X8, Canada

[3] Univ Toronto, Dept Pediat, Toronto, ON M5S 1A1, Canada

来源：

MECHANISMS OF DEVELOPMENT | 2001年 / 109卷 / 02期

基金：

加拿大健康研究院;

关键词：

mouse; eye; development; retina; Vsx1; Chx10; paired-like homeodomain; CVC domain; cone bipolar cell; evolution;

D O I：

10.1016/S0925-4773(01)00585-8

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The paired-like homeodomain (HD) protein Chx10 is distinguished by the presence of the CVC domain, a conserved 56 amino acid sequence C-terminal to the HD. In mammals. Chx10 is essential both for the proliferation of retinal progenitor cells and for the formation or survival of retinal bipolar interneurons. We describe the cloning and characterization of a mouse Chx10 homologue, Vsx1; phylogenetic analysis suggests that Vsx1 and its putative vertebrate orthologues have evolved rapidly. Vsx1 expression in the adult is predominantly retinal. Whereas Chx10 is expressed both in retinal progenitors in the developing eye and apparently in all bipolar cells of the mature retina, Vsx1 expression is first detected in the eye at postnatal day 5, where it is restricted to cone bipolar cells. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：315 / 322

页数：8

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