The long noncoding RNA landscape in cardiovascular disease: a brief update

被引：28

作者：

Salamon, Irene ^{[1
,2
]}

Jotti, Gloria Saccani ^{[3
]}

Condorelli, Gianluigi ^{[1
,2
,4
]}

机构：

[1] Humanitas Res Hosp, Dept Cardiovasc Med, Via Manzoni 56, I-20089 Milan, Italy

[2] Humanitas Univ, Milan, Italy

[3] Univ Parma, Dept Med & Surg Biotechnol & Translat Sci, Parma, Italy

[4] Natl Res Council Italy, Inst Genet & Biomed Res, Milan, Italy

来源：

CURRENT OPINION IN CARDIOLOGY | 2018年 / 33卷 / 03期

基金：

欧洲研究理事会;

关键词：

cardiovascular disease; long noncoding RNA; study approach; EXPRESSION; IDENTIFICATION; MATURATION; REGULATOR; ANRIL; SEQ;

D O I：

10.1097/HCO.0000000000000507

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Purpose of reviewIn this review, we summarize new knowledge on long noncoding RNAs (lncRNAs) linked to cardiovascular disease, in particular to heart failure.Recent findingsLncRNAs are dysregulated in specific developmental and pathological conditions and regulate critical responses to stress. LncRNAs are being recognized as molecules regulating myocardial remodeling during disease, participating for instance in the regulation of cardiomyocyte hypertrophy and function and fibroblast proliferation.SummaryLncRNAs add a new layer of complexity to the regulation of the biological processes underlying normal cardiac development and myocardial remodeling during disease; they may represent targets for novel therapeutic strategies for cardiovascular diseases.

引用

页码：282 / 289

页数：8

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