Factors affecting IL-1-mediated collagen metabolism by fibroblasts and the pathogenesis of periodontal disease: A review of the literature

被引:61
作者
HavemosePoulsen, A
Holmstrup, P
机构
[1] Department of Periodontology, School of Dentistry, University of Copenhagen, 2200 Copenhagen N
关键词
periodontal disease; matrix metalloproteinases; interleukin-1; beta; fibroblasts; collagen metabolism;
D O I
10.1177/10454411970080020801
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Fibroblasts have been studied extensively for their contribution to connective tissue destruction in diseases where the metabolism of extracellular matrix components plays an essential part in their pathogenesis. A considerable dissolution, especially of collagen fibrils, is a well-known characteristic of the periodontal ligament and the gingival connective tissue in microbial-induced periodontal disease. Fibroblasts, responsible for the assembly of the extracellular matrix, are capable of responding directly to oral microbial challenges or indirectly, following activation of the host immune response, and can alter the composition of connective tissue in several ways: synthesis of inflammatory mediators, their receptors and antagonists; fibroblast proliferation; collagen synthesis; phagocytosis of collagen fibrils; and synthesis of proteolytic enzymes, including matrix metalloproteinases and their corresponding inhibitors. The contributions of these cellular fibroblastic properties to the pathogenesis of periodontal disease are reviewed in the context of the cytokine, interleukin-1, as the inflammatory regulator.
引用
收藏
页码:217 / 236
页数:20
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共 206 条
[1]  
ABRAHAM RT, 1987, J BIOL CHEM, V262, P2719
[2]   HISTOLOGIC COMPARISONS OF INTERPROXIMAL GINGIVAL TISSUES RELATED TO THE PRESENCE OR ABSENCE OF BLEEDING [J].
ABRAMS, K ;
CATON, J ;
POLSON, A .
JOURNAL OF PERIODONTOLOGY, 1984, 55 (11) :629-632
[3]   ACUTE-PHASE PROTEINS IN GINGIVAL CREVICULAR FLUID DURING EXPERIMENTALLY-INDUCED GINGIVITIS [J].
ADONOGIANAKI, E ;
MOUGHAL, NA ;
MOONEY, J ;
STIRRUPS, DR ;
KINANE, DF .
JOURNAL OF PERIODONTAL RESEARCH, 1994, 29 (03) :196-202
[4]   GROWTH-FACTOR EFFECTS ON THE EXPRESSION OF COLLAGENASE AND TIMP-1 IN PERIODONTAL-LIGAMENT CELLS [J].
ALVARES, O ;
KLEBE, R ;
GRANT, G ;
COCHRAN, DL .
JOURNAL OF PERIODONTOLOGY, 1995, 66 (07) :552-558
[5]   INTERPROXIMAL GINGIVAL INFLAMMATION RELATED TO THE CONVERSION OF A BLEEDING TO A NONBLEEDING STATE [J].
AMATO, R ;
CATON, J ;
POLSON, A ;
ESPELAND, M .
JOURNAL OF PERIODONTOLOGY, 1986, 57 (02) :63-68
[6]   LIPOPOLYSACCHARIDE INDUCES HUMAN INTERLEUKIN-1 RECEPTOR ANTAGONIST AND INTERLEUKIN-1 PRODUCTION IN THE SAME CELL [J].
ANDERSSON, J ;
BJORK, L ;
DINARELLO, CA ;
TOWBIN, H ;
ANDERSSON, U .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1992, 22 (10) :2617-2623
[7]   PHORBOL ESTER INDUCIBLE GENES CONTAIN A COMMON CIS ELEMENT RECOGNIZED BY A TPA-MODULATED TRANS-ACTING FACTOR [J].
ANGEL, P ;
IMAGAWA, M ;
CHIU, R ;
STEIN, B ;
IMBRA, RJ ;
RAHMSDORF, HJ ;
JONAT, C ;
HERRLICH, P ;
KARIN, M .
CELL, 1987, 49 (06) :729-739
[8]   THE GENE STRUCTURE OF TISSUE INHIBITOR OF METALLOPROTEINASES (TIMP)-3 AND ITS INHIBITORY ACTIVITIES DEFINE THE DISTINCT TIMP GENE FAMILY [J].
APTE, SS ;
OLSEN, BR ;
MURPHY, G .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (24) :14313-14318
[9]   INTERLEUKIN-1 RECEPTOR ANTAGONIST - A NEW MEMBER OF THE INTERLEUKIN-1 FAMILY [J].
AREND, WP .
JOURNAL OF CLINICAL INVESTIGATION, 1991, 88 (05) :1445-1451
[10]   BIOLOGICAL PROPERTIES OF RECOMBINANT HUMAN MONOCYTE-DERIVED INTERLEUKIN-1 RECEPTOR ANTAGONIST [J].
AREND, WP ;
WELGUS, HG ;
THOMPSON, RC ;
EISENBERG, SP .
JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (05) :1694-1697