Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands

被引：17

作者：

Bakshi, RK ^{[1
]}

Hong, QM

Tang, R

Kalyani, RN

MacNeil, T

Weinberg, DH

Van der Ploeg, LHT

Patchett, AA

Nargund, RP

机构：

[1] Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USA

[2] Merck Res Labs, Dept Obes & Metab Res, Rahway, NJ 07065 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 05期

关键词：

privileged structure; melanocortin-4;

D O I：

10.1016/j.bmcl.2005.11.095

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Design and synthesis of potent MC4 selective agonists based on cyclohexylpiperidine derived cyclic urea, oxazolidinones, and sulfonamide based privileged structures are disclosed. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1130 / 1133

页数：4

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