Worldwide human papillomavirus genotype attribution in over 2000 cases of intraepithelial and invasive lesions of the vulva

被引：281

作者：

de Sanjose, Silvia ^{[1
,2
]}

Alemany, Laia ^{[1
,2
]}

Ordi, Jaume ^{[3
]}

Tous, Sara ^{[1
]}

Alejo, Maria ^{[4
]}

Bigby, Susan M. ^{[5
]}

Joura, Elmar Armin ^{[6
]}

Maldonado, Paula ^{[7
]}

Laco, Jan ^{[8
,9
]}

Bravo, Ignacio G. ^{[1
]}

Vidal, August ^{[10
]}

Guimera, Nuria ^{[11
]}

Cross, Paul ^{[12
]}

Wain, Gerard V. ^{[13
]}

Petry, Karl Ulrich ^{[14
]}

Mariani, Luciano ^{[15
]}

Bergeron, Christine ^{[16
]}

Mandys, Vaclav ^{[17
,18
]}

Rosa Sica, Adela ^{[19
]}

Felix, Ana ^{[20
]}

Usubutun, Alp ^{[21
]}

Seoud, Muhieddine ^{[22
]}

Hernandez-Suarez, Gustavo ^{[23
]}

Nowakowski, Andrzej Marcin ^{[24
]}

Wilson, Godfrey ^{[25
]}

Dalstein, Veronique ^{[26
]}

Hampl, Monika ^{[27
]}

Sachiko Kasamatsu, Elena ^{[28
]}

Lombardi, Luis Estuardo ^{[29
]}

Tinoco, Leopoldo ^{[30
]}

Alvarado-Cabrero, Isabel ^{[31
]}

Perrotta, Myriam ^{[32
]}

Bhatla, Neerja ^{[33
]}

Agorastos, Theodoros ^{[34
]}

Lynch, Charles F. ^{[35
]}

Goodman, Marc T. ^{[36
]}

Shin, Hai-Rim ^{[37
,38
]}

Viarheichyk, Halina ^{[39
]}

Jach, Robert ^{[40
]}

Eugenia Cruz, M. O. L. ^{[41
]}

Velasco, Julio ^{[42
]}

Molina, Carla ^{[43
]}

Bornstein, Jacob ^{[44
,45
]}

Ferrera, Annabelle ^{[46
]}

Domingo, Efren Javier ^{[47
]}

Cheng-Yang, Chou ^{[48
]}

Banjo, Adekunbiola F. ^{[49
]}

Castellsague, Xavier ^{[1
]}

Pawlita, Michael ^{[50
]}

Lloveras, Belen ^{[51
]}

机构：

[1] IDIBELL, Catalan Inst Oncol, Canc Epidemiol Res Program, Unit Infect & Canc, Barcelona, Spain

[2] CIBERESP, Barcelona, Spain

[3] Univ Barcelona, CRESIB Hosp Clin, Dept Pathol, E-08007 Barcelona, Spain

[4] Hosp Gen Hosp, Lhospitalet De Llobregat, Spain

[5] Middlemore Hosp, Lab Serv, Auckland 6, New Zealand

[6] Med Univ Vienna, Dept Obstet & Gynaecol, Ctr Comprehens Canc, Vienna, Austria

[7] Univ Fed Rio de Janeiro, Inst Ginecol, Rio De Janeiro, Brazil

[8] Charles Univ Prague, Fac Med, Fingerland Dept Pathol, CR-11636 Prague 1, Czech Republic

[9] Fac Hosp Hradec Kralove, Hradec Kralove, Czech Republic

[10] Hosp Univ Bellvitge, Lhospitalet De Llobregat, Spain

[11] DDL Diagnost Lab, Rijswijk, Netherlands

[12] Queen Elizabeth Hosp, Dept Cellular Pathol, Gateshead, Tyne & Wear, England

[13] Westmead Hosp, Westmead, NSW 2145, Australia

[14] Klinikum Wolfsburg, Wolfsburg, Germany

[15] Regina Elena Canc Ist, Rome, Italy

[16] Lab Cerba, Dept Pathol, Cergy Pontoise, France

[17] Fac Med 3, Dept Pathol, Prague, Czech Republic

[18] Fac Hosp Kings Wineyards, Prague, Czech Republic

[19] Hosp Mujer, Lab Anat Patolo, Montevideo, Uruguay

[20] Inst Portugues Oncol Francisco Gentil, Lisbon, Portugal

[21] Hacettepe Univ, Sch Med, Dept Pathol, Ankara, Turkey

[22] American Univ, Beirut Med Ctr, Beirut, Lebanon

[23] Inst Nacl Cancerol, Bogota, Colombia

[24] Med Univ Lublin, Lublin, Poland

[25] Manchester Royal Infirm, Manchester M13 9WL, Lancs, England

[26] CHU Reims, Lab Pol Bouin, INSERM UMR S 903, Reims, France

[27] Univ Dusseldorf, Dept Obstet & Gynecol, Dusseldorf, Germany

[28] Univ Nacl Asunc, Inst Invest Ciencias Salud, Asuncion, Paraguay

[29] Hosp Gen San Juan de Dios, Ctr Invest Epidemiol Salud Sexual & Reprod CIESAR, Guatemala City, Guatemala

[30] Hosp Oncol Solca, Quito, Ecuador

[31] Inst Mexicano Seguro Social, Mexico City, DF, Mexico

[32] Hosp Italiano Buenos Aires, Buenos Aires, DF, Argentina

[33] All India Inst Med Sci, New Delhi 110029, India

[34] Aristotle Univ Thessaloniki, GR-54006 Thessaloniki, Greece

[35] Univ Iowa, Coll Publ Hlth, Dept Epidemiol, Iowa City, IA 52242 USA

[36] Univ Hawaii, Canc Res Ctr Hawaii, Program Epidemiol, Honolulu, HI 96822 USA

[37] Natl Canc Ctr, Seoul, South Korea

[38] WHO Philippines, Manila, Philippines

[39] Gomel State Med Univ, Gomel, BELARUS

[40] Jagiellonian Univ, Coll Med, Krakow, Poland

[41] Ctr Reg Oncol Coimbra, Coimbra, Portugal

[42] Hosp San Agustin, Aviles, Spain

[43] Univ Chile, Fac Med, Ctr Oncol Prevent, Santiago, Chile

[44] Bar Ilan Univ, Western Galilee Hosp, Nahariyya, Israel

[45] Bar Ilan Univ, Fac Med, Nahariyya, Israel

[46] Univ Nacl Autonoma Honduras, Escuela Microbiol, Tegucigalpa, Honduras

[47] Univ Philippine, Coll Med, Gen Hosp, Manila, Philippines

[48] Natl Cheng Kung Univ, Coll Med, Taiwan Assoc Gynecol Oncologists, Tainan 70101, Taiwan

[49] Univ Lagos, Teaching Hosp, Lagos, Nigeria

[50] DKFZ, Virus Host Interact Polyoma & Papilloma Viruses, Heidelberg, Germany

来源：

EUROPEAN JOURNAL OF CANCER | 2013年 / 49卷 / 16期

关键词：

Papillomavirus; Vulva; p16(INK4a); SQUAMOUS-CELL CARCINOMA; NECK-CANCER; IN-SITU; NEOPLASIA; VACCINE; TRENDS; PREVALENCE; ASSAY; HEAD;

D O I：

10.1016/j.ejca.2013.06.033

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Human papillomavirus (HPV) contribution in vulvar intraepithelial lesions (VIN) and invasive vulvar cancer (IVC) is not clearly established. This study provides novel data on HPV markers in a large series of VIN and IVC lesions. Methods: Histologically confirmed VIN and IVC from 39 countries were assembled at the Catalan Institute of Oncology (ICO). HPV-DNA detection was done by polymerase chain reaction using SPF-10 broad-spectrum primers and genotyping by reverse hybridisation line probe assay (LiPA25) (version 1). IVC cases were tested for p16(INK4a) by immunohistochemistry (CINtec histology kit, ROCHE). An IVC was considered HPV driven if both HPV-DNA and p16(INK4a) overexpression were observed simultaneously. Data analyses included algorithms allocating multiple infections to calculate type-specific contribution and logistic regression models to estimate adjusted prevalence (AP) and its 95% confidence intervals (CI). Results: Of 2296 cases, 587 were VIN and 1709 IVC. HPV-DNA was detected in 86.7% and 28.6% of the cases respectively. Amongst IVC cases, 25.1% were both HPV-DNA and p16(INK4a) positive. IVC cases were largely keratinising squamous cell carcinoma (KSCC) (N = 1234). Overall prevalence of HPV related IVC cases was highest in younger women for any histological subtype. SCC with warty or basaloid features (SCC_WB) (N = 326) were more likely to be HPV and p16(INK4a) positive (AP = 69.5%, CI = 63.6-74.8) versus KSCC (AP = 11.5%, CI = 9.7-13.5). HPV 16 was the commonest type (72.5%) followed by HPV 33 (6.5%) and HPV 18 (4.6%). Enrichment from VIN to IVC was significantly high for HPV 45 (8.5-fold). Conclusion: Combined data from HPV-DNA and p16(INK4a) testing are likely to represent a closer estimate of the real fraction of IVC induced by HPV. Our results indicate that HPV contribution in invasive vulvar cancer has probably been overestimated. HPV 16 remains the major player worldwide. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：3450 / 3461

页数：12

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