A new anti-tubulin agent containing the benzo[b]thiophene ring system

被引：119

作者：

Pinney, KG

Bounds, AD

Dingeman, KM

Mocharla, VP

Pettit, GR

Bai, R

Hamel, E

机构：

[1] Baylor Univ, Dept Chem, Waco, TX 76798 USA

[2] Arizona State Univ, Canc Res Inst, Tempe, AZ 85287 USA

[3] Arizona State Univ, Dept Chem, Tempe, AZ 85287 USA

[4] NCI, Lab Drug Discovery Res & Dev, Dev Therapeut Proram,Div Canc Treatment & Diag, Frederick Canc Res & Dev Ctr, Ft Detrick, MD 21702 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(99)00143-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new type of inhibitor of tubulin polymerization was discovered based on the 3-aroyl-2-arylbenzo[b]thiophene molecular skeleton. The lead compound in this series, 2-(4'-methoxyphenyl)-3-(3',4',5'-trimethoxybenzoyl)-6-methoxybenzo[b]thio 1, inhibited tubulin polymerization, caused an increase in the mitotic index of CA46 Burkitt lymphoma cells, and inhibited the growth of several human cancer cell lines. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：1081 / 1086

页数：6

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