Unlocking the secrets of longevity genes

被引:80
作者
Sinclair, DA
Guarente, L
机构
[1] Harvard Univ, Sch Med, Paul F Glenn Labs Biol Mech Aging, Cambridge, MA 02138 USA
[2] Broad Inst Cambridge, Cambridge, MA USA
关键词
D O I
10.1038/scientificamerican0306-48
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
A handful of genes that control the body's defenses during hard times can also dramatically improve health and prolong life in diverse organisms. Understanding how they work may reveal the keys to extending human life span while banishing diseases of old age. One such gene is SIR2.
引用
收藏
页码:48 / +
页数:8
相关论文
共 4 条
[1]   Calorie restriction, SIRT1 and metabolism: Understanding longevity [J].
Bordone, L ;
Guarente, L .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (04) :298-305
[2]  
GUARENTE L, 2002, AGELESS QUEST ONE SC
[3]   The secrets of aging [J].
Rovner, SL .
CHEMICAL & ENGINEERING NEWS, 2004, 82 (34) :30-35
[4]   Toward a unified theory of caloric restriction and longevity regulation [J].
Sinclair, DA .
MECHANISMS OF AGEING AND DEVELOPMENT, 2005, 126 (09) :987-1002