Leptin and cancer

被引：495

作者：

Garofalo, C

Surmacz, E ^{[1
]}

机构：

[1] Temple Univ, Coll Sci & Technol, Sbarro Inst Canc Res & Mol Med, Philadelphia, PA 19122 USA

[2] Univ Calabria, Dept Pharmaco Biol, I-87036 Arcavacata Di Rende, Italy

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2006年 / 207卷 / 01期

关键词：

D O I：

10.1002/jcp.20472

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The prevalence of obesity has markedly increased over the past two decades, especially in the industrialized countries. While the impact of excess body weight on the development of cardiac disease and diabetes has been well documented, the link between obesity and carcinogenesis is just being recognized. This review will focus on the link between leptin, a cytokine that is elevated in obese individuals, and cancer development. First, we briefly discuss the biological functions of leptin and its signaling pathways. Then, we summarize the effects of leptin on different cancer types in experimental cellular and animal models. Next, we analyze epidemiological data on the relationship between obesity and the presence of cancer or cancer risk in patients. Finally, leptin as a target for cancer treatment and prevention will be discussed.

引用

收藏

页码：12 / 22

页数：11

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