Toll-like receptors: mammalian 'taste receptors' for a smorgasbord of microbial invaders

被引：66

作者：

Sieling, PA ^{[1
]}

Modlin, RL ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Sch Med, Dept Microbiol & Immunol, Inst Mol Biol,Div Dermatol,Dept Med, Los Angeles, CA 90095 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2002年 / 5卷 / 01期

关键词：

D O I：

10.1016/S1369-5274(02)00288-6

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In Drosophila, the Toll family of proteins is responsible for the recognition of bacteria and fungi. In mammals, Toll-like receptors (TLRs) are able to recognize and respond to microbial pathogens. Recent findings have defined the relationship between many TLRs and their microbial ligands, as well as the effect of TLR ligation on host defense. These findings have also provided a framework for determining how TLRs may by used to therapeutically modulate immune responses to infection.

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页码：70 / 75

页数：6

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