RNA-binding proteins SOP-2 and SOR-1 form a novel PcG-like complex in C-elegans

被引：13

作者：

Zhang, TT ^{[1
]}

Sun, YY ^{[1
]}

Tian, E ^{[1
]}

Deng, HS ^{[1
]}

Zhang, YX ^{[1
]}

Luo, X ^{[1
]}

Cai, QC ^{[1
]}

Wang, HY ^{[1
]}

Chai, JJ ^{[1
]}

Zhang, H ^{[1
]}

机构：

[1] Natl Inst Biol Sci, Beijing, Peoples R China

来源：

DEVELOPMENT | 2006年 / 133卷 / 06期

关键词：

sor-1; PcG; nuclear bodies; SAM domain; C; elegans;

D O I：

10.1242/dev.02275

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We describe the identification and characterization of a novel PcG gene in C. elegans, sor-1, which is involved in global repression of Hox genes. sor-1 encodes a novel protein with an RNA-binding activity. We provide evidence that SOR-1 and the previously identified RNA-binding protein SOP-2 may constitute an RNA-binding complex in Hox gene repression. SOR-1 and SOP-2 directly interact with each other and are colocalized in nuclear bodies. The localization of SOR-1 depends on SOP-2. Surprisingly, homologs of SOR-1 and SOP-2 are not found in other organisms, including the congeneric species C. briggsae, suggesting an unexpected lack of evolutionary constraint on an essential global gene regulatory system.

引用

页码：1023 / 1033

页数：11

共 42 条

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