Enantioselective catalysis.: Part 143:: Astonishingly high enantioselectivity in the transfer hydrogenation of acetophenone with 2-propanol using Ru complexes of the Schiff base derived from (S)-2-amino-2-hydroxy-1,1′-binaphthyl (NOBIN) and 2-pyridinecarbaldehyde

被引：63

作者：

Brunner, H ^{[1
]}

Henning, F ^{[1
]}

Weber, M ^{[1
]}

机构：

[1] Univ Regensburg, Inst Anorgan Chem, D-93040 Regensburg, Germany

来源：

TETRAHEDRON-ASYMMETRY | 2002年 / 13卷 / 01期

关键词：

D O I：

10.1016/S0957-4166(02)00029-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of bidentate and tridentate (S)-NOBIN derivatives was synthesised and tested as chiral ligands in the Ru-catalysed enantioselective transfer hydrogenation of acetophenone with 2-propanol. Despite the similarities in chemical structure, only the imine derived from (S)-NOBIN and 2-pyridinecarbaldehyde and the corresponding amine (obtained by NaBH4 reduction of the imine) afforded (S)-l-phenylethanol in nearly quantitative yields and outstanding enantioselectivities of up to 97% e.e. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：37 / 42

页数：6

共 19 条

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