Enantioselective catalysis.: Part 143:: Astonishingly high enantioselectivity in the transfer hydrogenation of acetophenone with 2-propanol using Ru complexes of the Schiff base derived from (S)-2-amino-2-hydroxy-1,1′-binaphthyl (NOBIN) and 2-pyridinecarbaldehyde

被引:63
作者
Brunner, H [1 ]
Henning, F [1 ]
Weber, M [1 ]
机构
[1] Univ Regensburg, Inst Anorgan Chem, D-93040 Regensburg, Germany
关键词
D O I
10.1016/S0957-4166(02)00029-0
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
A series of bidentate and tridentate (S)-NOBIN derivatives was synthesised and tested as chiral ligands in the Ru-catalysed enantioselective transfer hydrogenation of acetophenone with 2-propanol. Despite the similarities in chemical structure, only the imine derived from (S)-NOBIN and 2-pyridinecarbaldehyde and the corresponding amine (obtained by NaBH4 reduction of the imine) afforded (S)-l-phenylethanol in nearly quantitative yields and outstanding enantioselectivities of up to 97% e.e. (C) 2002 Elsevier Science Ltd. All rights reserved.
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页码:37 / 42
页数:6
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