The coexistence of systemic sclerosis and rheumatoid arthritis in five patients - Clinical and immunogenetic features suggest a distinct entity

被引：42

作者：

Horiki, T

Moriuchi, J

Takaya, M

Uchiyama, M

Hoshina, Y

Inada, K

Inoko, H

Tsuji, K

Ichikawa, Y

机构：

[1] Tokai University, School of Medicine, Isehara, Kanagawa

[2] Department of Internal Medicine 4, Tokai University, School of Medicine, Isehara, Kanagawa

来源：

ARTHRITIS AND RHEUMATISM | 1996年 / 39卷 / 01期

关键词：

D O I：

10.1002/art.1780390121

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To elucidate the clinical characteristics and pathogenesis of scleroderma-rheumatoid arthritis (SSc-RA) overlap syndrome, we analyzed the clinical features of 5 patients with SSc-RA overlap. Their HLA phenotypes and genotypes were also determined. Generalized skin sclerosis, severe seropositive polyarthritis, pulmonary fibrosis, anti-topoisomerase I antibodies, and HLA-DR4,53;DQA1*0301;DQB1*04 haplotype were observed in all of the patients. Similar clinical features were recognized in most of the 10 cases reported previously, Our case studies indicate that SSc-RA overlap may be a distinct entity.

引用

页码：152 / 156

页数：5

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