Photolithographic synthesis of peptoids

被引：51

作者：

Li, SW

Bowerman, D

Marthandan, N

Klyza, S

Luebke, KJ

Garner, HR

Kodadek, T

机构：

[1] Univ Texas, SW Med Ctr, Ctr Biomed Invent, Dallas, TX 75390 USA

[2] Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75390 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 13期

关键词：

D O I：

10.1021/ja039565w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We describe a novel photolithographic approach to the synthesis of peptoids (oligo-N-substituted glycines). This strategy enables the construction of a spatially addressable peptoid microarray, thus providing a potentially powerful tool for the discovery of protein ligands. Copyright © 2004 American Chemical Society.

引用

收藏

页码：4088 / 4089

页数：2

相关论文

共 24 条

[1] Isolation of protein ligands from large peptoid libraries [J].

Alluri, PG ;

Reddy, MM ;

Bachhawat-Sikder, K ;

Olivos, HJ ;

Kodadek, T .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (46) :13995-14004

[2] Parallel assessment of CpG methylation by two-color hybridization with oligonucleotide arrays [J].

Balog, RP ;

de Souza, YEP ;

Tang, HM ;

DeMasellis, GM ;

Gao, B ;

Avila, A ;

Gaban, DJ ;

Mittelman, D ;

Minna, JD ;

Luebke, KJ ;

Garner, HR .

ANALYTICAL BIOCHEMISTRY, 2002, 309 (02) :301-310

[3] A one-bead, one-stock solution approach to chemical genetics:: part 1 [J].

Blackwell, HE ;

Pérez, L ;

Stavenger, RA ;

Tallarico, JA ;

Eatough, EC ;

Foley, MA ;

Schreiber, SL .

CHEMISTRY & BIOLOGY, 2001, 8 (12) :1167-1182

[4] A one-bead, one-stock solution approach to chemical genetics: part 2 [J].

Clemons, PA ;

Koehler, AN ;

Wagner, BK ;

Sprigings, TG ;

Spring, DR ;

King, RW ;

Schreiber, SL ;

Foley, MA .

CHEMISTRY & BIOLOGY, 2001, 8 (12) :1183-1195

[5]

Figliozzi GM, 1996, METHOD ENZYMOL, V267, P437

[6] LIGHT-DIRECTED, SPATIALLY ADDRESSABLE PARALLEL CHEMICAL SYNTHESIS [J].

FODOR, SPA ;

READ, JL ;

PIRRUNG, MC ;

STRYER, L ;

LU, AT ;

SOLAS, D .

SCIENCE, 1991, 251 (4995) :767-773

[7] Development of protein-detecting microarrays and related devices [J].

Kodadek, T .

TRENDS IN BIOCHEMICAL SCIENCES, 2002, 27 (06) :295-300

[8] Protein microarrays: prospects and problems [J].

Kodadek, T .

CHEMISTRY & BIOLOGY, 2001, 8 (02) :105-115

[9] Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays [J].

Kuruvilla, FG ;

Shamji, AF ;

Sternson, SM ;

Hergenrother, PJ ;

Schreiber, SL .

NATURE, 2002, 416 (6881) :653-657

[10] A NEW TYPE OF SYNTHETIC PEPTIDE LIBRARY FOR IDENTIFYING LIGAND-BINDING ACTIVITY [J].

LAM, KS ;

SALMON, SE ;

HERSH, EM ;

HRUBY, VJ ;

KAZMIERSKI, WM ;

KNAPP, RJ .

NATURE, 1991, 354 (6348) :82-84