Fluorescence-lifetime-based tomography for turbid media

被引：74

作者：

Kumar, ATN ^{[1
]}

Skoch, J

Bacskai, BJ

Boas, DA

Dunn, AK

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA

[2] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Alzheimers Dis Res Unit,Dept Neurol, Charlestown, MA 02129 USA

来源：

OPTICS LETTERS | 2005年 / 30卷 / 24期

关键词：

D O I：

10.1364/OL.30.003347

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Received June 27, 2005; revised manuscript received August 17, 2005; accepted August 18, 2005 We derive a novel algorithm to recover the in vivo distributions of fluorophores based on an asymptotic lifetime analysis of time-domain fluorescence measurements with turbid tissue. We experimentally demonstrate the advantage offered by this method in localizing fluorophores with distinct lifetimes. This algorithm has wide applicability for diagnostic fluorescence imaging in the presence of several-centimeter-thick biological tissue, since fluorescence lifetime is a sensitive indicator of local tissue environment and interactions at the molecular level. (c) 2005 Optical Society of America.

引用

页码：3347 / 3349

页数：3

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