Disruption of latent inhibition in rats with postnatal hippocampal lesions

被引：82

作者：

Grecksch, G ^{[1
]}

Bernstein, HG ^{[1
]}

Becker, A ^{[1
]}

Höllt, V ^{[1
]}

Bogerts, B ^{[1
]}

机构：

[1] Otto Von Guericke Univ, Fac Med, Inst Pharmacol & Toxicol, D-39120 Magdeburg, Germany

来源：

NEUROPSYCHOPHARMACOLOGY | 1999年 / 20卷 / 06期

关键词：

schizophrenia; rat; postnatal hippocampal lesion; ibotenic acid; latent inhibition; shuttle box;

D O I：

10.1016/S0893-133X(98)00081-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Disruption of latent inhibition has been proposed as a possible model of cognitive abnormalities that under lie positive symptoms of a schizophrenia. We tested neonatal hippocampal lesioned vats in a Intent inhibition paradigm. Lesions of the ventral hippocampus were induced by bilateral injections of ibotenic acid in 7 days old mts. The behavior of lesioned was was tested postpubertally. We found a hyperresponsiveness to dopaminergic stimulation by apomorphine in locomotion tests. Latent inhibition was tested using the acquisition of a conditioned reaction in a two-way shuttle box. Sham operated control animals showed after preexposure of the to-be-conditioned stimulus (combined tone and light stimulus) a low acquisition. Ibotenic acid lesioned animals learned the conditioned reaction with and without preexposure in the same way, indicating disturbed latent inhibition. These results demonstrate disturbances in early postnatal hippocampal lesioned rats comparable with those seen in schizophrenic patients, thus further validating this procedure as a useful animal model of some aspects of schizophrenia. (C) 1999 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

引用

页码：525 / 532

页数：8

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