Dizocilpine (MK-801) prevents the development of sensitization to ethanol in DBA/2J mice

被引：44

作者：

Broadbent, J

Weitemier, AZ

机构：

[1] Oregon Hlth Sci Univ, Dept Behav Neurosci, Portland, OR 97201 USA

[2] Oregon Hlth Sci Univ, Portland Alcohol Res Ctr, Portland, OR 97201 USA

来源：

ALCOHOL AND ALCOHOLISM | 1999年 / 34卷 / 03期

关键词：

D O I：

10.1093/alcalc/34.3.283

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

DBA/2J mice repeatedly exposed to ethanol (2 g/kg, i.p. every 48 h for 8 days) exhibit sensitization to the locomotor stimulant effects of ethanol. Pretreatment with the NMDA receptor antagonist dizocilpine (0.2-0.3? mg/kg, i.p.) completely prevents the development of sensitization. Thus, NMDA receptors appear to play an important role in behavioural sensitization to ethanol.

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页码：283 / 288

页数：6

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