Cobalt-mediated alkylation of (4R) and (4S)-3-acetoacetyl-4-benzyloxazolidin-2-ones. Preparation of enantiopure diphenylmethyl-, 9-fluorenyl- and (1-adamantyl)glycines

被引：15

作者：

Galvez, N

MorenoManas, M

Vallribera, A

Molins, E

Cabrero, A

机构：

[1] UNIV AUTONOMA BARCELONA,DEPT CHEM,BARCELONA 08193,SPAIN

[2] CSIC,INST CIENCIA MAT,E-08193 CERDANYOLA,SPAIN

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 34期

关键词：

D O I：

10.1016/0040-4039(96)01322-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Co(II) completes of (4R) and (4S)-3-acetoacetyl-4-benzyloxazolidin-2-ones are alkylated diastereoselectively with diphenylmethyl. 9-fluorenyl, and 1-adamantyl bromide. The resulting products are converted into enantiopure alpha-substituted glycines. Similar results are obtained by alkylation of the free acetoacetyloxazolidinones under Co(II)-catalysis. Copyright (C) 1996 Elsevier Science Ltd

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页码：6197 / 6200

页数：4

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