Digital Microfluidics

被引：668

作者：

Choi, Kihwan ^{[1
,3
]}

Ng, Alphonsus H. C. ^{[2
,3
]}

Fobel, Ryan ^{[2
,3
]}

Wheeler, Aaron R. ^{[1
,2
,3
]}

机构：

[1] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada

[2] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada

[3] Terrence Donnelly Ctr Cellular & Biomol Res, Toronto, ON M5S 3E1, Canada

来源：

ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 5 | 2012年 / 5卷

关键词：

droplet; electrowetting on dielectric; dielectrophoresis; diagnosis; proteomics; bioanalysis; ON-A-CHIP; ELECTROWETTING-BASED ACTUATION; POLYMERASE-CHAIN-REACTION; DIGITIZED HEAT-TRANSFER; MALDI-MS; LIQUID DROPLETS; CLINICAL DIAGNOSTICS; PLURONIC ADDITIVES; THERMAL MANAGEMENT; MASS-SPECTROMETRY;

D O I：

10.1146/annurev-anchem-062011-143028

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Digital microfluidics (DMF) is an emerging liquid-handling technology that enables individual control over droplets on an open array of electrodes. These picoliter- to microliter-sized droplets, each serving as an isolated vessel for chemical processes, can be made to move, merge, split, and dispense from reservoirs. Because of its unique advantages, including simple instrumentation, flexible device geometry, and easy coupling with other technologies, DMF is being applied to a wide range of fields. In this review, we summarize the state of the art of DMF technology from the perspective of analytical chemistry in sections describing the theory of droplet actuation, device fabrication and integration, and applications.

引用

页码：413 / 440

页数：28

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