The development and function of follicular helper T cells in immune responses

被引：54

作者：

Chen, Maogen ^{[1
,2
]}

Guo, Zhiyong ^{[2
]}

Ju, Weiqiang ^{[2
]}

Ryffel, Bernhard ^{[3
,4
]}

He, Xiaoshun ^{[2
]}

Zheng, Song Guo ^{[1
]}

机构：

[1] Univ So Calif, Keck Sch Med, Div Rheumatol & Immunol, Dept Med, Los Angeles, CA 90033 USA

[2] Sun Yat Sen Univ, Affiliated Hosp 1, Organ Transplant Ctr, Guangzhou 510080, Guangdong, Peoples R China

[3] CNRS, F-45071 Orleans, France

[4] Univ Orleans, UMR6218, Orleans, France

来源：

CELLULAR & MOLECULAR IMMUNOLOGY | 2012年 / 9卷 / 05期

基金：

美国国家卫生研究院;

关键词：

autoimmune diseases; follicular helper T cells; systemic lupus erythematousus; CXC CHEMOKINE RECEPTOR-5; CENTER B-CELL; SYSTEMIC AUTOIMMUNITY; GERMINAL-CENTERS; PLASMA-CELLS; EXPRESSION; IL-21; DIFFERENTIATION; GENERATION; FOLLICLES;

D O I：

10.1038/cmi.2012.18

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Follicular helper T cells (Tfh) have been referred as a lineage that provides a help for B cells to proliferate and undergo antibody affinity maturation in the germinal center. Evidence has supported that Tfh subset development, like other lineages, is dependent on microenvironment where a particular transcriptional program is initiated. It has been shown that Bcl-6 and IL-21 act as master regulators for the development and function of Tfh cells. Tfh dysregulation is involved in the development of autoimmune pathologies, such as systemic lupus erythematosus, rheumatoid arthritis and other autoimmune diseases. The present review highlights the recent advances in the field of Tfh cells and focus on their development and function. Cellular & Molecular Immunology (2012) 9, 375-379; doi:10.1038/cmi.2012.18; published online 4 June 2012

引用

收藏

页码：375 / 379

页数：5

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