Opioid-induced hyperalgesia - A qualitative systematic review

被引:791
作者
Angst, MS [1 ]
Clark, JD [1 ]
机构
[1] Stanford Univ, Sch Med, Dept Anesthesia, Stanford, CA 94305 USA
关键词
D O I
10.1097/00000542-200603000-00025
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Opioids are the cornerstone therapy for the treatment of moderate to severe pain. Although common concerns regarding the use of opioids include the potential for detrimental side effects, physical dependence, and addiction, accumulating evidence suggests that opioids may yet cause another problem, often referred to as opioid-induced hyperalgesia. Somewhat paradoxically, opioid therapy aiming at alleviating pain may render patients more sensitive to pain and potentially may aggravate their preexisting pain. This review provides a comprehensive summary of basic and clinical research concerning opioid-induced hyperalgesia, suggests a framework for organizing pertinent information, delineates the status quo of our knowledge, identifies potential clinical implications, and discusses future research directions.
引用
收藏
页码:570 / 587
页数:18
相关论文
共 179 条
[1]  
Aley KO, 1997, J NEUROSCI, V17, P735
[2]  
Aley KO, 1997, J NEUROSCI, V17, P8018
[3]  
Aley KO, 1997, J NEUROSCI, V17, P3907
[4]  
Aley KO, 1995, J NEUROSCI, V15, P8031
[5]   The effect of opiates on the pain threshold in post-addicts [J].
Andrews, HL .
JOURNAL OF CLINICAL INVESTIGATION, 1943, 22 (04) :511-516
[6]   Short-term infusion of the μ-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal [J].
Angst, MS ;
Koppert, W ;
Pahl, I ;
Clark, DJ ;
Schmelz, M .
PAIN, 2003, 106 (1-2) :49-57
[7]   KAPPA-OPIOID RECEPTORS PARTICIPATE IN NERVE GROWTH FACTOR-INDUCED HYPERALGESIA [J].
APFEL, SC ;
NEWEL, M ;
DORMIA, C ;
KESSLER, JA .
NEUROSCIENCE, 1995, 68 (04) :1199-1206
[8]   CLINICAL-EXPERIENCE OF LONG-TERM TREATMENT WITH EPIDURAL AND INTRATHECAL OPIOIDS - A NATIONWIDE SURVEY [J].
ARNER, S ;
RAWAL, N ;
GUSTAFSSON, LL .
ACTA ANAESTHESIOLOGICA SCANDINAVICA, 1988, 32 (03) :253-259
[9]  
ARTS KS, 1991, J PHARMACOL EXP THER, V256, P890
[10]   HYPERALGESIA DURING NALOXONE-PRECIPITATED WITHDRAWAL FROM MORPHINE IS ASSOCIATED WITH INCREASED ON-CELL ACTIVITY IN THE ROSTRAL VENTROMEDIAL MEDULLA [J].
BEDERSON, JB ;
FIELDS, HL ;
BARBARO, NM .
SOMATOSENSORY AND MOTOR RESEARCH, 1990, 7 (02) :185-203