7-deaza-2′-deoxyguanosines functionalized with 7-(ω-aminoalk-1-ynyl) residues

被引：9

作者：

Ramzaeva, N ^{[1
]}

Mittelbach, C ^{[1
]}

Seela, F ^{[1
]}

机构：

[1] Univ Osnabruck, Inst Chem, Organ & Bioorgan Chem Lab, D-49069 Osnabruck, Germany

来源：

NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 6-7期

关键词：

D O I：

10.1080/07328319908044747

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Pd(0)-catalyzed cross coupling reaction of 7-iodo-7-deaza-2'-deoxyguanosine (1, I(7)c(7)G(d)) With the phthalimido-protected omega-aminoalkines 2a-c gave the compounds 3a-c. They were converted into the phosphoramidite building block 4a-c as well as the phosphonates 5a-c. Compounds 4a and 4c were incorporated into oligodeoxynucleotides of different sequence and their duplex stabilities were measured and compared with those of the unmodified counterparts.

引用

页码：1439 / 1440

页数：2

共 3 条

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