Assessment of fluctuating velocities in disturbed cardiovascular blood flow: In vivo feasibility of generalized phase-contrast MRI

被引：112

作者：

Dyverfeldt, Petter ^{[1
,2
]}

Kvitting, John-Peder Escobar ^{[1
,2
]}

Sigfridsson, Andreas ^{[1
,2
,3
]}

Engvall, Jan ^{[1
,2
]}

Bolger, Ann F. ^{[1
,4
]}

Ebbers, Tino ^{[1
,2
]}

机构：

[1] Linkoping Univ, Dept Med & Hlth Sci, Div Cardiovasc Med, SE-58185 Linkoping, Sweden

[2] Linkoping Univ, Ctr Med Image Sci & Visualizat, SE-58185 Linkoping, Sweden

[3] Linkoping Univ, Dept Biomed Engn, Div Med Informat, SE-58185 Linkoping, Sweden

[4] Univ Calif San Francisco, Dept Med, San Francisco, CA USA

来源：

JOURNAL OF MAGNETIC RESONANCE IMAGING | 2008年 / 28卷 / 03期

基金：

瑞典研究理事会;

关键词：

turbulent flow; cardiovascular disease; phase-contrast magnetic resonance imaging; stenosis; intravoxel velocity standard deviation mapping; turbulence;

D O I：

10.1002/jmri.21475

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose: To evaluate the feasibility of generalized phase-contrast magnetic resonance imaging (PC-MRI) for the non-invasive assessment of fluctuating velocities in cardiovascular blood flow. Materials and Methods: Multidimensional PC-MRI was used in a generalized manner to map mean flow velocities and intravoxel velocity standard deviation (IVSD) values in one healthy aorta and in three patients with different cardiovascular diseases. The acquired data were used to assess the kinetic energy of both the mean (MKE) and the fluctuating (TKE) velocity field. Results: In all of the subjects. both mean and fluctuating flow data were successfully acquired. The highest TKE values in the patients were found at sites characterized by abnormal flow conditions. No regional increase in TKE was found in the normal aorta. Conclusion: PC-MRI IVSD mapping is able to detect flow abnormalities in a variety of human cardiovascular conditions and shows promise for the quantitative assessment of turbulence. This approach may assist in clarifying the role of disturbed hemodynamics in cardiovascular diseases.

引用

页码：655 / 663

页数：9

共 42 条

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