Survivin regulation of vascular injury

被引：37

作者：

Conte, Michael S.

Altieri, Dario C.

机构：

[1] Univ Massachusetts, Sch Med, Dept Canc Biol, Worcester, MA 01605 USA

[2] Univ Massachusetts, Sch Med, Ctr Canc, Worcester, MA 01605 USA

[3] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Vasc Surg, Boston, MA 02115 USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2006年 / 16卷 / 04期

关键词：

D O I：

10.1016/j.tcm.2006.02.002

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Survivin is a protein member of the inhibitor of apoptosis family that has attracted attention for its dual essential roles in the regulation of cell division and the control of apoptosis. Although extensively characterized as a tumor gene and exploited for new opportunities in cancer diagnostics and therapeutics, fresh experimental evidence has uncovered a critical role of survivin in vascular cell responses in vivo. Dynamically embedded in broad signaling pathways controlling smooth muscle cell adaptation, survivin not only controls vascular wall homeostasis but also acts as a critical upstream regulator of gene expression and second mediators.

引用

页码：114 / 117

页数：4

共 40 条

[1]

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[2]

Acute ablation of survivin uncovers p53-dependent mitotic checkpoint functions and control of mitochondrial apoptosis [J].