3-benzamido, ureido and thioureidoimidazo[1,2-a]pyridine derivatives as potential antiviral agents

被引：11

作者：

Chaouni-Benabdallah, A

Galtier, C

Allouchi, H

Kherbeche, A

Chavignon, O

Teulade, JC

Witvrouw, M

Pannecouque, C

Snoeck, R

Andrei, G

Balzarini, J

De Clercq, E

Fauvelle, F

Enguehard, C

Gueiffier, A

机构：

[1] Fac Pharm Tours, EA Grp Rech Chim Heterocycl & Therapeut, Chim Therapeut Lab, F-37200 Tours, France

[2] Univ Sidi Mohamed Ben Abdellah, Ecole Super Technol Fes, Lab Catalyse & Environm, Fes, Morocco

[3] Fac Pharm Tours, Chim Phys Lab, F-37200 Tours, France

[4] Fac Pharm Clermont Ferrand, Chim Organ Lab, F-63001 Clermont Ferrand, France

[5] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium

[6] BCM, Ctr Rech Serv Sante Armees, F-38702 La Tronche, France

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2001年 / 49卷 / 12期

关键词：

imidazo[1,2-a]pyridine; cytomegalovirus; phenylthioureido; crystallographic data;

D O I：

10.1248/cpb.49.1631

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This work reports the synthesis and the antiviral activities of 3-benzamido, 3-phenylureido and 3-phenyl-thioureido derivatives in the imidazo[1,2-a]pyridine series. The structure was proven by NMR spectroscopy. The synthesized compounds were evaluated against a large number of viruses. The 3-phenylthioureido derivative 7 showed moderate activity against human cytomegalovirus (HCMV) in vitro. The crystallographic data for 8 are also reported and explain the absence of activity against human immunodeficiency virus (HIV).

引用

页码：1631 / 1635

页数：5

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