New perspectives in the modulation of the eicosanoid cascade in inflammation

被引：1

作者：

Clària, J ^{[1
]}

López-Parra, M ^{[1
]}

机构：

[1] Univ Barcelona, DNA Unit, Hosp Clin, IDIBAPS, E-08036 Barcelona, Spain

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2005年 / 2卷 / 05期

关键词：

eicosanoids; prostaglandins; leukotrienes; lipoxins; resolvins; inflammation;

D O I：

10.2174/1570180054405730

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cyclooxygenase and 5-lipoxygenase pathways, which convert arachidonic acid into prostaglandins and leukotrienes, respectively, are the two major pro-inflammatory routes, whereas lipoxins, resolvins and neuroprotectins are potent endogenous anti-inflammatory mediators. Modulation of these pathways is key to control inflammation and to promote its resolution.

引用

页码：391 / 402

页数：12

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