NS3 of Bluetongue Virus Interferes with the Induction of Type I Interferon

被引：62

作者：

Chauveau, Emilie ^{[1
]}

Doceul, Virginie ^{[1
]}

Lara, Estelle ^{[1
]}

Breard, Emmanuel ^{[1
]}

Sailleau, Corinne ^{[1
]}

Vidalain, Pierre-Olivier ^{[2
]}

Meurs, Eliane F. ^{[3
]}

Dabo, Stephanie ^{[3
]}

Schwartz-Cornil, Isabelle ^{[4
]}

Zientara, Stephan ^{[1
]}

Vitour, Damien ^{[1
]}

机构：

[1] INRA, ENVA, UMR Virol 1161, Maisons Alfort Lab Anim Hlth,ANSES, Maisons Alfort, France

[2] Inst Pasteur, CNRS, URA 3015, Unit Viral Genom & Vaccinat, Paris, France

[3] Inst Pasteur, CNRS, URA 3015, Unit Hepacivirus & Innate Immun, Paris, France

[4] INRA, UR892, Jouy En Josas, France

来源：

JOURNAL OF VIROLOGY | 2013年 / 87卷 / 14期

关键词：

TOLL-LIKE RECEPTOR; RIG-I; DENDRITIC CELLS; ADAPTER PROTEIN; KAPPA-B; RECOGNITION; INFECTION; RESPONSES; HISTORY; BOVINE;

D O I：

10.1128/JVI.00678-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Upon infection with Bluetongue virus (BTV), an arthropod-borne virus, type I interferon (IFN-I) is produced in vivo and in vitro. IFN-I is essential for the establishment of an antiviral cellular response, and most if not all viruses have elaborated strategies to counteract its action. In this study, we assessed the ability of BTV to interfere with IFN-I synthesis and identified the nonstructural viral protein NS3 as an antagonist of the IFN-I system.

引用

页码：8241 / 8246

页数：6

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