Militarinone A, a neurotrophic pyridone alkaloid from Paecilomyces militaris

被引：82

作者：

Schmidt, K

Gunther, W

Stoyanova, S

Schubert, B

Li, ZZ

Hamburger, M ^{[1
]}

机构：

[1] Univ Jena, Inst Pharm, D-00773 Jena, Germany

[2] Univ Jena, Inst Organ & Macromol Chem, D-00773 Jena, Germany

[3] Anhui Agr Univ, Res Ctr Entomogenous Fungi, Hefei 230036, Anhui, Peoples R China

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 02期

关键词：

D O I：

10.1021/ol016920j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A new pyridone alkaloid, militarinone A (1), was isolated by bioassay-guided fractionation from the mycelium of the entomogenous fungus Paecilomyces militaris. Its structure was established by extensive spectroscopic analysis. The compound features an unprecedented side chain and a 1,4-substituted cyclohexyl moiety not previously encountered in microbial metabolites. Militarinone A had a pronounced neurotrophic effect in PC-12 cells at 10 muM concentrations.

引用

页码：197 / 199

页数：3

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