Developmental alterations in NMDA receptor-mediated currents in neonatal rat spinal motoneurons

被引：30

作者：

Hori, Y ^{[1
]}

Kanda, K ^{[1
]}

机构：

[1] TOKYO METROPOLITAN INST GERONTOL,DEPT CENT NERVOUS SYST,ITABASHI,TOKYO 125,JAPAN

来源：

NEUROSCIENCE LETTERS | 1996年 / 205卷 / 02期

关键词：

N-methyl-D-aspartate receptor; spinal motoneurons; postnatal development; whole-cell patch-clamp;

D O I：

10.1016/0304-3940(96)12388-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Postnatal development of N-methyl-D-aspartate (NMDA) receptors expressed in motoneurons was studied by tight-seal whole-cell recordings from identified motoneurons in slices of neonatal rat spinal cord. The magnitude of NMDA-induced currents was large during the early postnatal period, and then it decreased gradually through postnatal day (PND) 15. The pharmacological properties of NMDA-induced currents altered during this period, suggesting that the combination of NMDA receptor subunits changes during development. The magnitude of the NMDA receptor-mediated component of excitatory postsynaptic current evoked by electrical stimulation of an adjacent neuron also decreased from PNDs 1-5 through PNDs 11-15. NMDA receptors appear to underlie the mechanisms of activity-dependent development of spinal motoneurons during early postnatal life.

引用

页码：99 / 102

页数：4

共 19 条

[1] LONG-TERM POTENTIATION AND NMDA RECEPTORS IN RAT VISUAL-CORTEX [J].

ARTOLA, A ;

SINGER, W .

NATURE, 1987, 330 (6149) :649-652

[2] THE POSTNATAL-GROWTH OF MOTONEURONS AT 3 LEVELS OF THE CAT NEURAXIS [J].

CAMERON, WE ;

HE, F ;

BROZANSKI, BS ;

GUTHRIE, RD .

NEUROSCIENCE LETTERS, 1989, 104 (03) :274-280

[3]

COLLINGRIDGE GL, 1989, PHARMACOL REV, V41, P143

[4] PRENATAL AND POSTNATAL-DEVELOPMENT OF LAMINA-IX NEURONS IN THE RAT THORACIC SPINAL-CORD [J].

CUMMINGS, JP ;

STELZNER, DJ .

EXPERIMENTAL NEUROLOGY, 1984, 83 (01) :155-166

[5]

FLAMENT D, 1992, EXP BRAIN RES, V90, P225

[6] DISTRIBUTION OF NMDA RECEPTOR-BINDING IN DEVELOPING MOUSE SPINAL-CORD [J].

GONZALEZ, DL ;

FUCHS, JL ;

DROGE, MH .

NEUROSCIENCE LETTERS, 1993, 151 (02) :134-137

[7] DEVELOPMENTAL REGULATION OF NMDA RECEPTOR-MEDIATED SYNAPTIC CURRENTS AT A CENTRAL SYNAPSE [J].

HESTRIN, S .

NATURE, 1992, 357 (6380) :686-689

[8] MINIATURE POSTSYNAPTIC CURRENTS RECORDED FROM IDENTIFIED RAT SPINAL DORSAL HORN PROJECTION NEURONS IN THIN-SLICE PREPARATIONS [J].

HORI, Y ;

ENDO, K .

NEUROSCIENCE LETTERS, 1992, 142 (02) :191-195

[9] N-METHYL-D-ASPARTATE RECEPTORS ARE TRANSIENTLY EXPRESSED IN THE DEVELOPING SPINAL-CORD VENTRAL HORN [J].

KALB, RG ;

LIDOW, MS ;

HALSTED, MJ ;

HOCKFIELD, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (18) :8502-8506

[10] INDUCTION OF A NEURONAL PROTEOGLYCAN BY THE NMDA RECEPTOR IN THE DEVELOPING SPINAL-CORD [J].

KALB, RG ;

HOCKFIELD, S .

SCIENCE, 1990, 250 (4978) :294-296

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