Hepatic stellate cells: role in microcirculation and pathophysiology of portal hypertension

被引：219

作者：

Reynaert, H

Thompson, MG

Thomas, T

Geerts, A

机构：

[1] Free Univ Brussels, Univ Hosp, Dept Gastroenterol Hepatol, AZ VUB,Lab Mol Liver Cell Biol, B-1090 Brussels, Belgium

[2] Newcastle Univ, Dept Med Cell Biol, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[3] Newcastle Univ, Liver Res Ctr, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

来源：

GUT | 2002年 / 50卷 / 04期

关键词：

D O I：

10.1136/gut.50.4.571

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Accumulating evidence suggests that stellate cells are involved in the regulation of the liver microcirculation and portal hypertension. Activated hepatic stellate cells have the necessary machinery to contract or relax in response to a number of vasoactive substances. Because stellate cells play a role in both fibrosis and portal hypertension, they are currently regarded as therapeutic targets to prevent and treat the complications of chronic liver disease.

引用

页码：571 / 581

页数：11

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