Enantiopure trans- and cis-3-aminoindan-1-ols:: Preparation and application as novel basic resolving agents

被引:18
作者
Kinbara, K [1 ]
Katsumata, Y [1 ]
Saigo, K [1 ]
机构
[1] Univ Tokyo, Grad Sch Frontier Sci, Dept Integrated Biosci, Bunkyo Ku, Tokyo 1138656, Japan
关键词
D O I
10.1246/cl.2002.266
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
trans- and cis-3-Aminoindan-1-ols were prepared by moderately selective reductions of 3-aminoindan-1-one derivatives and separated into enantiopure forms. The enantiopure transisomer had a moderate resolving ability for 2-arylalkanoic acids having a naphthalene ring at the a-position. The X-ray crystallographic analysis showed that an infinite hydrogen-bond sheet was formed in the less-soluble salt, suggesting that the skeleton of these indanols would be favorable for the stabilization of the less-soluble salt by hydrogen-bonding interaction.
引用
收藏
页码:266 / 267
页数:2
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