Selective activation of apoptosis by a novel set of 4-aryl-3-(3-aryl-1-oxo-2-propenyl)-2(1H)-quinolinones through a Myc-dependent pathway

被引：70

作者：

Claassen, Gisela ^{[1
]}

Brin, Elena ^{[1
]}

Crogan-Grundy, Candace ^{[1
]}

Vaillancourt, Mei Ting ^{[1
]}

Zhang, Han Zhong ^{[1
]}

Cai, Sui Xiong ^{[1
]}

Drewe, John ^{[1
]}

Tseng, Ben ^{[1
]}

Kasibhatla, Shailaja ^{[1
]}

机构：

[1] EpiCept Corp, Dept Biol, San Diego, CA 92121 USA

来源：

CANCER LETTERS | 2009年 / 274卷 / 02期

关键词：

Caspases; Effectors of apoptosis; Oncogenes; Myc; Small molecule drugs; CHRONIC MYELOID-LEUKEMIA; C-MYC; BCR-ABL; MYC/MAX DIMERIZATION; TYROSINE KINASE; SMALL MOLECULES; TRANSFORMATION; PROTEOLYSIS; PROTEASOME; EXPRESSION;

D O I：

10.1016/j.canlet.2008.09.032

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Oncogene addiction due to Myc deregulation has been identified in a variety of tumor types. In order to identify pharmacological agents that cause selective apoptosis in tumors with deregulated Myc expression, we designed a cell-based screening assay based on our Anti-cancer Screening Apoptosis Program (ASAP) technology targeting increased activity in a "Myc-addicted" cancer cell panel. We have identified a novel set of substituted 4-aryl-3-(3-aryl-1-oxo-2-propenyl)-2(1H)-quinolinones that activates apoptosis in cancer cell lines with deregulated Myc, but show low activity in cell lines where Myc is not deregulated. Apoptosis induced by these compounds is rapid, and is associated with a significant downregulation of Myc protein. Selective knockdown of Myc levels in these cells by RNA interference increased sensitivity to apoptosis with compound treatment. By targeting the Myc pathway in Myc-addicted cancer cells, we have identified a novel class of apoptotic inducers that selectively and efficiently target cancer cells with deregulated Myc. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：243 / 249

页数：7

共 41 条

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