The association of frailty with serum 25-hydroxyvitamin D and parathyroid hormone levels in older European men

被引：75

作者：

Tajar, Abdelouahid ^{[1
]}

Lee, David M. ^{[2
]}

Pye, Stephen R. ^{[3
]}

O'Connell, Matthew D. L. ^{[3
]}

Ravindrarajah, Rathi ^{[3
]}

Gielen, Evelien ^{[4
]}

Boonen, Steven ^{[4
]}

Vanderschueren, Dirk ^{[4
]}

Pendleton, Neil ^{[5
]}

Finn, Joseph D. ^{[3
]}

Bartfai, Gyoergy ^{[6
]}

Casanueva, Felipe F. ^{[7
]}

Forti, Gianni ^{[8
]}

Giwercman, Aleksander ^{[9
]}

Han, Thang S. ^{[10
,11
]}

Huhtaniemi, Ilpo T. ^{[12
]}

Kula, Krzysztof ^{[13
]}

Lean, Michael E. J. ^{[14
]}

Punab, Margus ^{[15
]}

Wu, Frederick C. W. ^{[16
]}

O'Neill, Terence W. ^{[17
]}

机构：

[1] Univ Oxford, Oxford, England

[2] Univ Manchester, Arthrit Res UK Epidemiol Unit, Manchester M13 9PT, Lancs, England

[3] Univ Manchester, Manchester, Lancs, England

[4] Katholieke Univ Leuven, Louvain, Belgium

[5] Salford Royal Hosp NHS Trust, Manchester, Lancs, England

[6] Albert Szent Gyorgyi Med Univ, Dept Obstet Gynaecol & Androl, H-6701 Szeged, Hungary

[7] Univ Santiago de Compostela, Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CB06 03, Dept Med,CHUS, Santiago De Compostela, Spain

[8] Univ Florence, Florence, Italy

[9] Lund Univ, Lund, Sweden

[10] Royal Free, London, England

[11] Univ Coll Hosp Med Sch, London, England

[12] Univ London Imperial Coll Sci Technol & Med, London, England

[13] Med Univ Lodz, Lodz, Poland

[14] Univ Glasgow, Glasgow, Lanark, Scotland

[15] Tartu Univ Clin, United Labs, Tartu, Estonia

[16] Univ Manchester, MAHSC, Androl Res Unit, Dev & Regenerat Biomed Res Grp, Manchester, Lancs, England

[17] Univ Manchester, MAHSC, Arthritis Res UK Epidemiol Unit, Manchester, Lancs, England

来源：

AGE AND AGEING | 2013年 / 42卷 / 03期

关键词：

frailty; vitamin D; parathyroid hormone; population-based; male health; ageing; EMAS; older people; VITAMIN-D DEFICIENCY; PHYSICAL PERFORMANCE; MUSCLE STRENGTH; DISABILITY; FRACTURES; ADULTS; RISK;

D O I：

10.1093/ageing/afs162

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background: the link between the vitamin D endocrine axis and frailty remains undefined, with few studies examining the joint effect of vitamin D and parathyroid hormone (PTH) levels. Our objective was to determine the association of frailty with serum 25-hydroxyvitamin D (25(OH) D) and PTH. Setting: cross-sectional analysis within the European Male Ageing Study (EMAS). Participants: a total of 1,504 community-dwelling men aged 60-79 years. Methods: frailty was classified using a frailty phenotype (FP) and frailty index (FI). The association of frailty with 25(OH)D and PTH was examined using multinomial logistic regression; individual FP criteria with 25(OH)D and PTH using binary logistic regression. Results were expressed as relative odds ratios (ROR) and 95% confidence intervals (CIs) for multinomial; odds ratios (OR) and 95% CIs for binary models. Results: using the FP, 5.0% of subjects were classified as frail and 36.6% as prefrail. Lower levels of 25(OH)D were associated with being prefrail (per 1 SD decrease: ROR = 1.45; 95% CI: 1.26-1.67) and frail (ROR = 1.89; 95% CI: 1.30-2.76), after adjusting for age, centre and health and lifestyle confounders (robust group = base category). Higher levels of PTH were associated with being frail after adjustment for confounders (per 1 SD increase: ROR = 1.24; 95% CI: 1.01-1.52). Comparable results were found using the FI. Among the five FP criteria only sarcopenia was not associated with 25(OH)D levels, while only weakness was associated with PTH. Conclusion: lower 25(OH)D and higher PTH levels were positively associated with frailty in older men. Prospective data would enable the temporal nature of this relationship to be explored further.

引用

页码：352 / 359

页数：8

共 33 条

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