Synthesis of α-tocopherol (vitamin E), vitamin K1-chromanol, and their analogs in the presence of aluminosilicate catalysts Tseokar-10 and Pentasil

被引：10

作者：

Odinokov, VN ^{[1
]}

Spivak, AV

Emelyanova, GA

Mallyabaeva, MI

Nazarova, OV

Dzhemilev, UM

机构：

[1] Bashkortostan Republ Acad Sci, Inst Petrochem & Catalysis, 141 Prosp Oktyabrya, Ufa 450075, Russia

[2] Russian Acad Sci, Ufa Sci Ctr, Ufa 450075, Russia

来源：

ARKIVOC | 2003年

关键词：

alpha-tocopherol; vitamin K-1-chromanol; Delta(3)-chromenes; condensation; aluminosilicate catalysts;

D O I：

10.3998/ark.5550190.0004.d11

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The highly effective heterogeneous catalysts, the aluminosilicates Tseokar-10 and Pentasil, were found to condense hydroquinones with tertiary isoprenoid allylic alcohols. Using these catalysts d,l-alpha-tocopherol, (2RS, 4'R, 8'R)-alpha-tocopherol, and vitamin K-1-chromanol with chiral homogeneous side chains were synthesized in high yields. The analogs of alpha-tocopherol-chromanols and chromenols with the terminal isopropylidene group in the side chain-were synthesized, whose selective ozonolysis resulted in the corresponding chromanes with omega-formyl- or omega-hydroxyl groups in the side chain.

引用

页码：101 / 118

页数：18

共 29 条

[1] SYNTHESES OF ACRIDONE AND CARBAZOLE ALKALOIDS INVOLVING PYRIDINE-CATALYZED CHROMEN FORMATION - CRYSTAL AND MOLECULAR-STRUCTURE OF DIBROMOCANNIBICYCLOL AND ITS BEARING ON STRUCTURES OF CYCLOL ALKALOIDS [J].