Macrophage roles following myocardial infarction

被引：295

作者：

Lambert, Jessica M. ^{[1
]}

Lopez, Elizabeth F. ^{[1
]}

Lindsey, Merry L. ^{[1
]}

机构：

[1] Univ Texas Hlth Sci Ctr San Antonio, Div Cardiol, Dept Med, San Antonio, TX 78229 USA

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2008年 / 130卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Macrophage; Myocardial infarction; Matrix metalloproteinases; Left ventricular remodeling; Angiogenesis; Fibrosis;

D O I：

10.1016/j.ijcard.2008.04.059

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Following myocardial infarction (MI), circulating blood monocytes respond to chemotactic factors, migrate into the infarcted myocardium, and differentiate into macrophages. At the injury site, macrophages remove necrotic cardiac myocytes and apoptotic neutrophils; secrete cytokines, chemokines, and growth factors; and modulate phases of the angiogenic response. As such, the macrophage is a primary responder cell type that is involved in the regulation of post-MI wound healing at multiple levels. This review summarizes what is currently known about macrophage functions post-MI and borrows literature from other injury and inflammatory models to speculate on additional roles. Basic science and clinical avenues that remain to be explored are also discussed. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：147 / 158

页数：12

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