Early and mid-term cardiovascular outcomes following TAVI: Impact of pre-procedural transvalvular gradient

Objective: To assess the relation of aortic transvalvular gradient with outcomes following transcatheter aortic valve implantation (TAVI). Background: Relatively little is known about the predictors of adverse outcomes in patients with severe aortic stenosis following TAVI. Methods: We studied 126 consecutive patients (mean age 83.2 +/- 6.3 years; 59% women) who underwent TAVI (23% transapical; 77% transfemoral) at our institution. All patients were followed for the incidence of major adverse cardiovascular events (MACE), including myocardial infarction, heart failure, stroke, and cardiovascular death. Results: The acute procedural success rate was 98%; at 1 year, the cumulative incidence of MACE and cardiovascular death was 29% and 10%, respectively. In multivariable analyses adjusting for clinical and echocardiographic risk factors, presence of a baseline mean transvalvular gradient (MTG) <40 mm Hg was a significant predictor of 30-day MACE in the total sample (OR 4.4, 95% CI 1.7-11.4; P=0.003) as well as in patients with an ejection fraction >= 50% (OR 10.3, 95% CI 3.0-33.4; P<0.001). In multivariable analyses, low MTG was also associated with 2-fold and 4-fold increased hazards for MACE (HR 4.2, 95% CI 2.0-8.9; P<0.001) and cardiovascular death (HR 4.2 95% CI 1.2-14.9; P=0.03), respectively, within 1 year following TAVI. Conclusion: Presence of a low MTG (<40 mm Hg) prior to TAVI was associated with a greater risk of major adverse events, including cardiovascular death, up to 1 year following the procedure. Pre-procedural MTG could be used to identify patients at a high risk for adverse outcomes following TAVI. (C) 2012 Elsevier Ireland Ltd. All rights reserved.