Remote electronic control of the ligand in the enantioselective palladium-catalyzed allylic alkylation with chiral oxazolinylpyridines

被引：21

作者：

Chelucci, G ^{[1
]}

Deriu, SP ^{[1
]}

Saba, A ^{[1
]}

Valenti, R ^{[1
]}

机构：

[1] Univ Sassari, Dipartimento Chim, I-07100 Sassari, Italy

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 08期

关键词：

D O I：

10.1016/S0957-4166(99)00116-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

New chiral oxazolinylpyridines bearing electron-donating and withdrawing groups lin the 4-position of the pyridine ring have been prepared and assessed in the enantioselective palladium catalyzed allylic substitution of 1,3-diphenylprop-2-enyl acetate with dimethyl malonate. The electronic properties of substituents strongly affect the catalytic activity and only slightly affect the enantioselectivity of the substitution reaction. Enantioselectivity up to 93% was obtained. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1457 / 1464

页数：8