Ontogenetic development of the response to anandamide and Delta(9)-tetrahydrocannabinol in mice

被引：33

作者：

Fride, E ^{[1
]}

Mechoulam, R ^{[1
]}

机构：

[1] HEBREW UNIV JERUSALEM,FAC MED,DEPT NAT PROD,IL-91120 JERUSALEM,ISRAEL

来源：

DEVELOPMENTAL BRAIN RESEARCH | 1996年 / 95卷 / 01期

关键词：

anandamide; antiemetic; behavior; cannabinoids; development; ontogeny; tetrahydrocannabinol;

D O I：

10.1016/0165-3806(96)00087-9

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We studied the ontogenetic response to cannabinoid receptor ligands by measuring motor activity and analgesia in response to anandamide or Delta(9)-THC from day 6 of age. No response to anandamide was observed up to the age of weaning (day 23), while a nonsignificant response to Delta(9)-THC was observed starting between days 15 and 20. This is compatible with observations that children respond to the antiemetic effects of THC without psychotropic side effects.

引用

页码：131 / 134

页数：4

共 20 条

[1] AN EFFICIENT NEW CANNABINOID ANTIEMETIC IN PEDIATRIC ONCOLOGY [J].

ABRAHAMOV, A ;

MECHOULAM, R .

LIFE SCIENCES, 1995, 56 (23-24) :2097-2102

[2] NEW HOT PLATE TESTS TO QUANTIFY ANTINOCICEPTIVE AND NARCOTIC-ANTAGONIST ACTIVITIES [J].

ANKIER, SI .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1974, 27 (01) :1-4

[3]

[Anonymous], CANNABINOID RECEPTOR

[4] Cannabinomimetic behavioral effects of and adenylate cyclase inhibition by two new endogenous anandamides [J].

Barg, J ;

Fride, E ;

Hanus, L ;

Levy, R ;

MatusLeibovitch, N ;

Heldman, E ;

Bayewitch, M ;

Mechoulam, R ;

Vogel, Z .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1995, 287 (02) :145-152

[5]

BELUE RC, 1994, NEUROTOXICOL TERATOL, V17, P25

[6] PRESENCE OF CANNABINOID BINDING-SITES IN THE BRAIN FROM EARLY POSTNATAL AGES [J].

DEFONSECA, FR ;

RAMOS, JA ;

BONNIN, A ;

FERNANDEZRUIZ, JJ .

NEUROREPORT, 1993, 4 (02) :135-138

[7] ISOLATION AND STRUCTURE OF A BRAIN CONSTITUENT THAT BINDS TO THE CANNABINOID RECEPTOR [J].

DEVANE, WA ;

HANUS, L ;

BREUER, A ;

PERTWEE, RG ;

STEVENSON, LA ;

GRIFFIN, G ;

GIBSON, D ;

MANDELBAUM, A ;

ETINGER, A ;

MECHOULAM, R .

SCIENCE, 1992, 258 (5090) :1946-1949

[8] FORMATION AND INACTIVATION OF ENDOGENOUS CANNABINOID ANANDAMIDE IN CENTRAL NEURONS [J].

DIMARZO, V ;

FONTANA, A ;

CADAS, H ;

SCHINELLI, S ;

CIMINO, G ;

SCHWARTZ, JC ;

PIOMELLI, D .

NATURE, 1994, 372 (6507) :686-691

[9]

EDDY NB, 1953, J PHARM, V98, P121

[10] MAST-CELLS EXPRESS A PERIPHERAL CANNABINOID RECEPTOR WITH DIFFERENTIAL SENSITIVITY TO ANANDAMIDE AND PALMITOYLETHANOLAMIDE [J].

FACCI, L ;

DALTOSO, R ;

ROMANELLO, S ;

BURIANI, A ;

SKAPER, SD ;

LEON, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (08) :3376-3380

← 1 2 →