Neuregulin-1, a Key Axonal Signal that Drives Schwann Cell Growth and Differentiation

被引：180

作者：

Birchmeier, Carmen ^{[1
]}

Nave, Klaus-Armin ^{[2
]}

机构：

[1] Max Delbrueck Ctr, D-13125 Berlin, Germany

[2] Max Planck Inst Expt Med, Dept Neurogenet, Gollingen, Germany

来源：

GLIA | 2008年 / 56卷 / 14期

关键词：

neuregulim; Schwann cell; myelination;

D O I：

10.1002/glia.20753

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Interactions between neuronal and glial cells are crucial for establishing a functional nervous system. Many aspects of Schwann cell development and physiology are regulated by neuronal signals; possibly the most spectacular is the elaboration of the myelin sheath. An extensive line of research has revealed that one neuronal factor, termed "neuregulin", promotes Schwann cell growth and survival, migration along the extending axon, and myelination. The versatility of glial responses elicited by this factor is thus clearly astounding. (c) 2008 Wiley-Liss, Inc.

引用

页码：1491 / 1497

页数：7

共 79 条

[1]

Adlkofer K, 2000, GLIA, V29, P104, DOI 10.1002/(SICI)1098-1136(20000115)29:2<104::AID-GLIA2>3.0.CO

[2]

2-2

[3] POTENTIAL OF SCHWANN-CELLS FROM UNMYELINATED NERVES TO PRODUCE MYELIN - QUANTITATIVE ULTRASTRUCTURAL AND RADIOGRAPHIC STUDY [J].